This proceeding contains some of the oral and poster presentations from the 5th National Big Data Health Science Conference (Columbia, SC, Feb 13-14, 2025) that was organized by the University of South Carolina Big Data Health Science Center (BDHSC). Proceedings of the 6th National Big Data Health Science Conference* were published on July 31, 2025, by BMC Proceedings, which is an online, open-access journal publishing proceedings of conferences across all scientific and clinical disciplines, including peer-reviewed full-length articles, collections of abstracts, and meeting reports. Conference proceedings are available at https://bmcproc.biomedcentral.com/articles/10.1186/s12919-025-00328-2#citeas.

*Citation: Proceedings of the 6th National Big Data Health Science Conference. BMC Proc 19 (Suppl 13), 20 (2025). https://doi.org/10.1186/s12919-025-00328-2